Iowa Cancer Registry

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Tissue Repository

Residual Tissue Repository (RTR) and Virtual Tissue Repository (VTR)

The Residual and Virtual Tissue Repositories (RTR, VTR) are a division of the Iowa Cancer Registry, a population-based and statewide cancer registry established in 1973. The Repositories are a core resource for cancer investigators whose work uses diagnostic tissue that is formalin fixed and paraffin embedded (FFPE).

The Residual and Virtual Tissue Repositories are closely associated with and receive support from the Iowa Health Care Holden Comprehensive Cancer Center (HCCC). Our work is particularly aligned with the HCCC Population Research Core.

The Residual Tissue Repository (RTR)
Since the mid-1990s, the Iowa Cancer Registry has retrieved FFPE cancer tissue from many hospitals and diagnostic pathology laboratories in Iowa. There are >500,000 FFPE tissue blocks archived by the Iowa Cancer Registry RTR, virtually all of which are >10 years old. These blocks are derived from >60,000 malignant tumors.

The Virtual Tissue Repository (VTR)
FFPE tissue blocks from recently diagnosed cancers (<10 years since diagnosis) are archived by hospitals and diagnostic pathology laboratories throughout Iowa. The Iowa Cancer Registry has long-standing relationships that facilitate research use of FFPE tissue blocks from some of these cancer cases. Investigators have potential access to >400,000 tumors via the VTR.

Most investigators who use RTR and/or VTR tissue blocks conduct immunohistochemistry studies on unstained slides or tissue cores. Some investigators conduct molecular studies. Histology services are available from the Histology Core Laboratory, a research histology resource in the University of Iowa Department of Pathology. This includes preparing unstained slides, tissue scrolls, H&E stained slides, project-specific immunohistochemistry stained slides, and obtaining tissue cores suitable for tissue microarray (TMA) studies.

Process for Accessing Tissue for Research

We request project-specific information in order to help us assess whether our resources may be of value to your investigation. To request tissue for research, please complete the tissue request application. [We realize that study protocols vary in stage of development and local approval, and that you may not be able to provide all requested information.] Once your inquiry is received, we will respond within 7 business days. Please note, the Iowa Cancer Registry provides access to tissue for the purpose of the collaborative academic research. We do not supply tissue to third party organizations, or industry vendors.

FAQs Regarding Tissue Annotation

FAQ pdf

Summary of Facilities and Resources

Facilities and Resources pdf

Contacts for Tissue Research

Marcus Nashelsky, MD
Medical Director, Iowa Cancer Registry
University of Iowa College of Public Health
(319) 353-7594
marcus-nashelsky@uiowa.edu

Michael O’Rorke, PhD
Assistant Professor of Epidemiology
University of Iowa College of Public Health
(319) 384-1560
michael-ororke@uiowa.edu

Publications

2023

Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, Jiang B, Goodman MT, Siburg-Saber M, Cozen W, Liu L, Lynch CF, Wentzensen N, Jordan RC, Altekruse S, Anderson WF, Rosenberg PS, Gillison ML. (2023) Human papillomavirus and rising oropharyngeal cancer incidence in the United States.  Journal of Clinical Oncology 2023 41(17):3081-3088.
PMID 37285653

Starrett GJ, Yu K, Golubeva Y, Lenz P, Piaskowski ML, Petersen D, Dean M, Israni A, Hernandez BY, Tucker TC, Cheng I, Gonsalves L, Morris CR, Hussain SK, Lynch CF, Harris RS, Prokunina-Olsson L, Meltzer PS, Buck CB, Engels EA (2023). Evidence for virus-mediated oncogenesis in bladder cancers arising in solid organ transplant recipients. eLife 2023 Mar 24;12:e82690.
PMID 36961501

2022
2021

Mahale, P., Nomburg, J., Song, J. Y., Steinberg, M., Starrett, G., Boland, J., Lynch, C. F., Chadburn, A., Rubinstein, P. G., Hernandez, B. Y., Weisenburger, D. D., Bullman, S., & Engels, E. A. (2021). Metagenomic analysis to identify novel infectious agents in systemic anaplastic large cell lymphoma. Infect Agent Cancer, 16(1), 65.
PMID 34775986

Mix, J. M., Saraiya, M., Thompson, T. D., Querec, T. D., Greek, A., Tucker, T. C., Peters, E. S., Lynch, C. F., Hernandez, B. Y., Copeland, G., Goodman, M. T., & Unger, E. R. (2021). Prevalence of human papillomavirus genotypes in high-grade cervical precancer and invasive cervical cancer from cancer registries before and after vaccine introduction in the United States. Cancer, 127(19), 3614-3621.
PMID 34289090

Oyenuga, M., Vierkant, R. A., Lynch, C. F., Pengo, T., Tillmans, L. S., Cerhan, J. R., Church, T. R., Lazovich, D., Anderson, K. E., Limburg, P. J., & Prizment, A. E. (2021). Associations between tissue-based CD3+ T-lymphocyte count and colorectal cancer survival in a prospective cohort of older women. Mol Carcinog, 60(1), 15-24.
PMID 33200476

Robinson, T. J., Wilson, L. E., Marcom, P. K., Troester, M., Lynch, C. F., Hernandez, B. Y., Parrilla, E., Brauer, H. A., & Dinan, M. A. (2021). Analysis of Sociodemographic, Clinical, and Genomic Factors Associated With Breast Cancer Mortality in the Linked Surveillance, Epidemiology, and End Results and Medicare Database. JAMA Netw Open, 4(10), e2131020.
PMID 34714340

Yoon, A. J., Santella, R. M., Wang, S., Kutler, D. I., Carvajal, R. D., Philipone, E., Wang, T., Peters, S. M., Stewart, C. R., Momen-Heravi, F., Troob, S., Levin, M., AkhavanAghdam, Z., Shackelford, A. J., Canterbury, C. R., Shimonosono, M., Hernandez, B. Y., McDowell, B. D., & Nakagawa, H. (2021). MicroRNA-Based Cancer Mortality Risk Scoring System and hTERT Expression in Early-Stage Oral Squamous Cell Carcinoma. J Oncol, 2021, 8292453.
PMID 33510789

Yuan, Y., Van Dyke, A. L., Petkov, V. I., Hussey, S., Moravec, R., Altekruse, S. F., Sandoval, M., Cress, R. D., Mueller, L. M., Mogi, A., Hernandez, B. Y., Selk, F. R., Lynch, C. F., Tucker, T. C., Lynch, M. A., Lefante, C., Wu, X. C., Sweeney, C., Doherty, J. A., & Penberthy, L. S. (2021). Pathology Laboratory Policies and Procedures for Releasing Diagnostic Tissue for Cancer Research. Arch Pathol Lab Med, 145(2), 222-226.
PMID 33501497

2020

Fackler, M. J., Cho, S., Cope, L., Gabrielson, E., Visvanathan, K., Wilsbach, K., Meir-Levi, D., Lynch, C. F., Marks, J., Geradts, J., Regan, M. M., Viale, G., Wolff, A. C., Sukumar, S., & Umbricht, C. B. (2020). DNA methylation markers predict recurrence-free interval in triple-negative breast cancer. Npj Breast Cancer, 6, 3.
PMID 32025567

Kagihara, J., Matsuda, B., Young, K. L., Li, X., Lao, X., Deshpande, G. A., Omata, F., Burnett, T., Lynch, C. F., Hernandez, B. Y., & Kuwada, S. K. (2020). Novel association between Helicobacter pylori infection and gastrointestinal stromal tumors (GIST) in a multi-ethnic population. Gastrointestinal Stromal Tumor, 3. https://gist.amegroups.com/article/view/45135

Yoon, A. J., Wang, S., Kutler, D. I., Carvajal, R. D., Philipone, E., Wang, T., Peters, S. M., LaRoche, D., Hernandez, B. Y., McDowell, B. D., Stewart, C. R., Momen-Heravi, F., & Santella, R. M. (2020). MicroRNA-based risk scoring system to identify early-stage oral squamous cell carcinoma patients at high-risk for cancer-specific mortality. Head Neck, 42(8), 1699-1712.
PMID 31981257

2019

Coghill, A. E., Bellizzi, A. M., Lynch, C. F., Shiels, M. S., Selk, F. R., Gillison, M., Hernandez, B. Y., Chan, O. T. M., & Engels, E. A. (2019). Pathology Characterization and Detection of Human Papillomavirus Type 16 in Rectal Squamous Cell Carcinomas. Clin Gastroenterol Hepatol, 17(10), 2129-2131.
PMID 30448596

Hernandez, B. Y., Lynch, C. F., Chan, O. T. M., Goodman, M. T., Unger, E. R., Steinau, M., Thompson, T. D., Gillison, M., Lyu, C., Saraiya, M., & Workgroup, H. P. V. T. o. C. (2019). Human papillomavirus DNA detection, p16(INK4a), and oral cavity cancer in a U.S. population. Oral Oncol, 91, 92-96.
PMID 30926069

Mix, J., Saraiya, M., Lynch, C. F., Thompson, T. D., Greek, A., Tucker, T. C., Peters, E. S., Querec, T. D., & Unger, E. R. (2019). Comparing Human Papillomavirus Prevalence in Rectal and Anal Cancer Using US Cancer Registries, 2014-2015. J Registry Manag, 46(4), 128-132.
PMID 32822337

2018

Hallowell, B. D., Saraiya, M., Thompson, T. D., Unger, E. R., Lynch, C. F., Tucker, T., Copeland, G., Hernandez, B. Y., Peters, E. S., Wilkinson, E., & Goodman, M. T. (2018). Population-Based Assessment of HPV Genotype-Specific Cervical Cancer Survival: CDC Cancer Registry Sentinel Surveillance System. JNCI Cancer Spectr, 2(3).
PMID 30596199

Piehowski, P. D., Petyuk, V. A., Sontag, R. L., Gritsenko, M. A., Weitz, K. K., Fillmore, T. L., Moon, J., Makhlouf, H., Chuaqui, R. F., Boja, E. S., Rodriguez, H., Lee, J. S. H., Smith, R. D., Carrick, D. M., Liu, T., & Rodland, K. D. (2018). Residual tissue repositories as a resource for population-based cancer proteomic studies. Clin Proteomics, 15, 26.
PMID 30087585

2017

Prizment, A. E., Vierkant, R. A., Smyrk, T. C., Tillmans, L. S., Nelson, H. H., Lynch, C. F., Pengo, T., Thibodeau, S. N., Church, T. R., Cerhan, J. R., Anderson, K. E., & Limburg, P. J. (2017). Cytotoxic T Cells and Granzyme B Associated with Improved Colorectal Cancer Survival in a Prospective Cohort of Older Women. Cancer Epidemiol Biomarkers Prev, 26(4), 622-631.
PMID 27979806

Quadri, H. S., Aiken, T. J., Allgaeuer, M., Moravec, R., Altekruse, S., Hussain, S. P., Miettinen, M. M., Hewitt, S. M., & Rudloff, U. (2017). Expression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical outcome in pancreatic cancer. BMC cancer, 17(1), 495.
PMID 28732488

Rossille, D., Azzaoui, I., Feldman, A. L., Maurer, M. J., Laboure, G., Parrens, M., Pangault, C., Habermann, T. M., Ansell, S. M., Link, B. K., Tarte, K., Witzig, T. E., Lamy, T., Slager, S. L., Roussel, M., Milpied, N., Cerhan, J. R., & Fest, T. (2017). Soluble programmed death-ligand 1 as a prognostic biomarker for overall survival in patients with diffuse large B-cell lymphoma: a replication study and combined analysis of 508 patients. Leukemia, 31(4), 988-991.
PMID 28035137

Siegel, D. A., Wilson, R., Wilkinson, E. J., Gargano, J. W., Watson, M., Hernandez, B. Y., Goodman, M. T., Lynch, C. F., Unger, E. R., & Saraiya, M. (2017). Evaluation of the Vulvar Cancer Histology Code Reported by Central Cancer Registries: Importance in Epidemiology. Arch Pathol Lab Med, 141(1), 139-143.
PMID 27763794

2016

Hernandez, B. Y., Rahman, M., Lynch, C. F., Cozen, W., Unger, E. R., Steinau, M., Thompson, T., Saber, M. S., Altekruse, S. F., Goodman, M. T., Powers, A., Lyu, C., & Saraiya, M. (2016). p16(INK4A) expression in invasive laryngeal cancer. Papillomavirus Res, 2, 52-55.
PMID 29034342

Prizment, A. E., Vierkant, R. A., Smyrk, T. C., Tillmans, L. S., Lee, J. J., Sriramarao, P., Nelson, H. H., Lynch, C. F., Thibodeau, S. N., Church, T. R., Cerhan, J. R., Anderson, K. E., & Limburg, P. J. (2016). Tumor eosinophil infiltration and improved survival of colorectal cancer patients: Iowa Women’s Health Study. Mod Pathol, 29(5), 516-527.
PMID 26916075

Yang, B., Shebl, F. M., Sternberg, L. R., Warner, A. C., Kleiner, D. E., Edelman, D. C., Gomez, A., Dagnall, C. L., Hicks, B. D., Altekruse, S. F., Hernandez, B. Y., Lynch, C. F., Meltzer, P. S., & McGlynn, K. A. (2016). Telomere Length and Survival of Patients with Hepatocellular Carcinoma in the United States. PloS one, 11(11), e0166828.
PMID 27880792

2015

Carrick, D. M., Mehaffey, M. G., Sachs, M. C., Altekruse, S., Camalier, C., Chuaqui, R., Cozen, W., Das, B., Hernandez, B. Y., Lih, C. J., Lynch, C. F., Makhlouf, H., McGregor, P., McShane, L. M., Phillips Rohan, J., Walsh, W. D., Williams, P. M., Gillanders, E. M., Mechanic, L. E., & Schully, S. D. (2015). Robustness of Next Generation Sequencing on Older Formalin-Fixed Paraffin-Embedded Tissue. PloS one, 10(7), e0127353.
PMID 26222067

Goodman, M. T., Saraiya, M., Thompson, T. D., Steinau, M., Hernandez, B. Y., Lynch, C. F., Lyu, C. W., Wilkinson, E. J., Tucker, T., Copeland, G., Peters, E. S., Altekruse, S., & Unger, E. R. (2015). Human papillomavirus genotype and oropharynx cancer survival in the United States of America. Eur J Cancer, 51(18), 2759-2767.
PMID 26602016

Graham, R. P., Vierkant, R. A., Tillmans, L. S., Wang, A. H., Laird, P. W., Weisenberger, D. J., Lynch, C. F., French, A. J., Slager, S. L., Raissian, Y., Garcia, J. J., Kerr, S. E., Lee, H. E., Thibodeau, S. N., Cerhan, J. R., Limburg, P. J., & Smyrk, T. C. (2015). Tumor Budding in Colorectal Carcinoma: Confirmation of Prognostic Significance and Histologic Cutoff in a Population-based Cohort. Am J Surg Pathol, 39(10), 1340-1346.
PMID 26200097

O’Leary, B. R., Fath, M. A., Bellizzi, A. M., Hrabe, J. E., Button, A. M., Allen, B. G., Case, A. J., Altekruse, S., Wagner, B. A., Buettner, G. R., Lynch, C. F., Hernandez, B. Y., Cozen, W., Beardsley, R. A., Keene, J., Henry, M. D., Domann, F. E., Spitz, D. R., & Mezhir, J. J. (2015). Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma. Clin Cancer Res, 21(7), 1741-1751.
PMID 25634994

Saraiya, M., Unger, E. R., Thompson, T. D., Lynch, C. F., Hernandez, B. Y., Lyu, C. W., Steinau, M., Watson, M., Wilkinson, E. J., Hopenhayn, C., Copeland, G., Cozen, W., Peters, E. S., Huang, Y., Saber, M. S., Altekruse, S., Goodman, M. T., & Workgroup, H. P. V. T. o. C. (2015). US assessment of HPV types in cancers: implications for current and 9-valent HPV vaccines. J Natl Cancer Inst, 107(6), djv086.
PMID 25925419

Tillmans, L. S., Vierkant, R. A., Wang, A. H., Samadder, N. J., Lynch, C. F., Anderson, K. E., French, A. J., Haile, R. W., Harnack, L. J., Potter, J. D., Slager, S. L., Smyrk, T. C., Thibodeau, S. N., Cerhan, J. R., & Limburg, P. J. (2015). Associations between Environmental Exposures and Incident Colorectal Cancer by ESR2 Protein Expression Level in a Population-Based Cohort of Older Women. Cancer Epidemiol Biomarkers Prev, 24(4), 713-719.
PMID 25650184

2014

Altekruse, S. F., Rosenfeld, G. E., Carrick, D. M., Pressman, E. J., Schully, S. D., Mechanic, L. E., Cronin, K. A., Hernandez, B. Y., Lynch, C. F., Cozen, W., Khoury, M. J., & Penberthy, L. T. (2014). SEER cancer registry biospecimen research: yesterday and tomorrow. Cancer Epidemiol Biomarkers Prev, 23(12), 2681-2687.
PMID 25472677

Hernandez, B. Y., Goodman, M. T., Lynch, C. F., Cozen, W., Unger, E. R., Steinau, M., Thompson, T., Saber, M. S., Altekruse, S. F., Lyu, C., Saraiya, M., & Workgroup, H. P. V. T. o. C. (2014). Human papillomavirus prevalence in invasive laryngeal cancer in the United States. PloS one, 9(12), e115931.
PMID 25546150

Hernandez, B. Y., Goodman, M. T., Unger, E. R., Steinau, M., Powers, A., Lynch, C. F., Cozen, W., Saber, M. S., Peters, E. S., Wilkinson, E. J., Copeland, G., Hopenhayn, C., Huang, Y., Watson, M., Altekruse, S. F., Lyu, C., Saraiya, M., & Workgroup, H. P. V. T. o. C. (2014). Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based United States population. Front Oncol, 4, 9.
PMID 24551592

Hopenhayn, C., Christian, A., Christian, W. J., Watson, M., Unger, E. R., Lynch, C. F., Peters, E. S., Wilkinson, E. J., Huang, Y., Copeland, G., Cozen, W., Saber, M. S., Goodman, M. T., Hernandez, B. Y., Steinau, M., Lyu, C., Tucker, T. T., & Saraiya, M. (2014). Prevalence of human papillomavirus types in invasive cervical cancers from 7 US cancer registries before vaccine introduction. Journal of lower genital tract disease, 18(2), 182-189. https://doi.org/10.1097/LGT.0b013e3182a577c7

Jia, J., Bosley, A. D., Thompson, A., Hoskins, J. W., Cheuk, A., Collins, I., Parikh, H., Xiao, Z., Ylaya, K., Dzyadyk, M., Cozen, W., Hernandez, B. Y., Lynch, C. F., Loncarek, J., Altekruse, S. F., Zhang, L., Westlake, C. J., Factor, V. M., Thorgeirsson, S., . . . Amundadottir, L. T. (2014). CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells. Cancer Res, 74(10), 2785-2795.
PMID 24648346

Mbulaiteye, S. M., Pullarkat, S. T., Nathwani, B. N., Weiss, L. M., Rao, N., Emmanuel, B., Lynch, C. F., Hernandez, B., Neppalli, V., Hawes, D., Cockburn, M. G., Kim, A., Williams, M., Altekruse, S., Bhatia, K., Goodman, M. T., & Cozen, W. (2014). Epstein-Barr virus patterns in US Burkitt lymphoma tumors from the SEER residual tissue repository during 1979-2009. APMIS, 122(1), 5-15.
PMID 23607450

Sinno, A. K., Saraiya, M., Thompson, T. D., Hernandez, B. Y., Goodman, M. T., Steinau, M., Lynch, C. F., Cozen, W., Saber, M. S., Peters, E. S., Wilkinson, E. J., Copeland, G., Hopenhayn, C., Watson, M., Lyu, C., & Unger, E. R. (2014). Human papillomavirus genotype prevalence in invasive vaginal cancer from a registry-based population. Obstet Gynecol, 123(4), 817-821.
PMID 24785610

Steinau, M., Saraiya, M., Goodman, M. T., Peters, E. S., Watson, M., Cleveland, J. L., Lynch, C. F., Wilkinson, E. J., Hernandez, B. Y., Copeland, G., Saber, M. S., Hopenhayn, C., Huang, Y. J., Cozen, W., Lyu, C., Unger, E. R., & Workgrp, H. T. C. (2014). Human Papillomavirus Prevalence in Oropharyngeal Cancer before Vaccine Introduction, United States. Emerging infectious diseases, 20(5), 822-828. https://doi.org/10.3201/eid2005.131311

Tillmans, L. S., Vierkant, R. A., Wang, A. H., Jewel Samadder, N., Lynch, C. F., Anderson, K. E., French, A. J., Haile, R. W., Harnack, L. J., Potter, J. D., Slager, S. L., Smyrk, T. C., Thibodeau, S. N., Cerhan, J. R., & Limburg, P. J. (2014). Associations between cigarette smoking, hormone therapy, and folate intake with incident colorectal cancer by TP53 protein expression level in a population-based cohort of older women. Cancer Epidemiol Biomarkers Prev, 23(2), 350-355. PMID 24343843

2013

de Sanjose, S., Alemany, L., Ordi, J., Tous, S., Alejo, M., Bigby, S. M., Joura, E. A., Maldonado, P., Laco, J., Bravo, I. G., Vidal, A., Guimera, N., Cross, P., Wain, G. V., Petry, K. U., Mariani, L., Bergeron, C., Mandys, V., Sica, A. R., . . . group, H. V. s. (2013). Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva. Eur J Cancer, 49(16), 3450-3461.
PMID 23886586

Esser, A. K., Miller, M. R., Huang, Q., Meier, M. M., Beltran-Valero de Bernabe, D., Stipp, C. S., Campbell, K. P., Lynch, C. F., Smith, B. J., Cohen, M. B., & Henry, M. D. (2013). Loss of LARGE2 disrupts functional glycosylation of alpha-dystroglycan in prostate cancer. J Biol Chem, 288(4), 2132-2142.
PMID 23223448

Henderson, G. E., Cadigan, R. J., Edwards, T. P., Conlon, I., Nelson, A. G., Evans, J. P., Davis, A. M., Zimmer, C., & Weiner, B. J. (2013). Characterizing biobank organizations in the U.S.: results from a national survey. Genome Med, 5(1), 3.
PMID 23351549

Matsuno, R. K., Sherman, M. E., Visvanathan, K., Goodman, M. T., Hernandez, B. Y., Lynch, C. F., Ioffe, O. B., Horio, D., Platz, C., Altekruse, S. F., Pfeiffer, R. M., & Anderson, W. F. (2013). Agreement for tumor grade of ovarian carcinoma: analysis of archival tissues from the surveillance, epidemiology, and end results residual tissue repository. Cancer Causes Control, 24(4), 749-757.
PMID 23378140

Samadder, N. J., Vierkant, R. A., Tillmans, L. S., Wang, A. H., Weisenberger, D. J., Laird, P. W., Lynch, C. F., Anderson, K. E., French, A. J., Haile, R. W., Potter, J. D., Slager, S. L., Smyrk, T. C., Thibodeau, S. N., Cerhan, J. R., & Limburg, P. J. (2013). Associations between colorectal cancer molecular markers and pathways with clinicopathologic features in older women. Gastroenterology, 145(2), 348-356 e341-342.
PMID 23665275

Steinau, M., Unger, E. R., Hernandez, B. Y., Goodman, M. T., Copeland, G., Hopenhayn, C., Cozen, W., Saber, M. S., Huang, Y., Peters, E. S., Lynch, C. F., Wilkinson, E. J., Rajeevan, M. S., Lyu, C., & Saraiya, M. (2013). Human papillomavirus prevalence in invasive anal cancers in the United States before vaccine introduction. J Low Genit Tract Dis, 17(4), 397-403.
PMID 23609590

2012

Altirriba, J., Garcia, A., Sanchez, B., Haba, L., Altekruse, S., Stratmann, T., Bombi, J. A., Mezquita, C., Gomis, R., & Mora, C. (2012). The sole presence of CDK4 is not a solid criterion for discriminating between tumor and healthy pancreatic tissues. Int J Cancer, 130(11), 2743-2745. PMID 21792898

Cerhan, J. R., Natkunam, Y., Morton, L. M., Maurer, M. J., Asmann, Y., Habermann, T. M., Vasef, M. A., Cozen, W., Lynch, C. F., Allmer, C., Slager, S. L., Lossos, I. S., Chanock, S. J., Rothman, N., Hartge, P., Dogan, A., & Wang, S. S. (2012). LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era. Leuk Lymphoma, 53(6), 1105-1112.
PMID 22066713

Cubilla, A. L., Lloveras, B., Alemany, L., Alejo, M., Vidal, A., Kasamatsu, E., Clavero, O., Alvarado-Cabrero, I., Lynch, C., Velasco-Alonso, J., Ferrera, A., Chaux, A., Klaustermeier, J., Quint, W., de Sanjose, S., Munoz, N., & Bosch, F. X. (2012). Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. Am J Surg Pathol, 36(6), 869-875.
PMID 22367299

Gargano, J. W., Wilkinson, E. J., Unger, E. R., Steinau, M., Watson, M., Huang, Y., Copeland, G., Cozen, W., Goodman, M. T., Hopenhayn, C., Lynch, C. F., Hernandez, B. Y., Peters, E. S., Saber, M. S., Lyu, C. W., Sands, L. A., & Saraiya, M. (2012). Prevalence of human papillomavirus types in invasive vulvar cancers and vulvar intraepithelial neoplasia 3 in the United States before vaccine introduction. J Low Genit Tract Dis, 16(4), 471-479.
PMID 22652576

Iakovlev, V., Siegel, E. R., Tsao, M. S., & Haun, R. S. (2012). Expression of kallikrein-related peptidase 7 predicts poor prognosis in patients with unresectable pancreatic ductal adenocarcinoma. Cancer Epidemiol Biomarkers Prev, 21(7), 1135-1142.
PMID 22573795

Limburg, P. J., Limsui, D., Vierkant, R. A., Tillmans, L. S., Wang, A. H., Lynch, C. F., Anderson, K. E., French, A. J., Haile, R. W., Harnack, L. J., Potter, J. D., Slager, S. L., Smyrk, T. C., Thibodeau, S. N., & Cerhan, J. R. (2012). Postmenopausal hormone therapy and colorectal cancer risk in relation to somatic KRAS mutation status among older women. Cancer Epidemiol Biomarkers Prev, 21(4), 681-684.
PMID 22337533

Limsui, D., Vierkant, R. A., Tillmans, L. S., Wang, A. H., Weisenberger, D. J., Laird, P. W., Lynch, C. F., Anderson, K. E., French, A. J., Haile, R. W., Harnack, L. J., Potter, J. D., Slager, S. L., Smyrk, T. C., Thibodeau, S. N., Cerhan, J. R., & Limburg, P. J. (2012). Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women. Gut, 61(9), 1299-1305.
PMID 22027477

Razzak, A. A., Oxentenko, A. S., Vierkant, R. A., Tillmans, L. S., Wang, A. H., Weisenberger, D. J., Laird, P. W., Lynch, C. F., Anderson, K. E., French, A. J., Haile, R. W., Harnack, L. J., Potter, J. D., Slager, S. L., Smyrk, T. C., Thibodeau, S. N., Cerhan, J. R., & Limburg, P. J. (2012). Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women’s Health Study. Nutr Cancer, 64(7), 899-910. https://doi.org/10.1080/01635581.2012.714833 PMID 23061900

Samadder, N. J., Vierkant, R. A., Tillmans, L. S., Wang, A. H., Lynch, C. F., Anderson, K. E., French, A. J., Haile, R. W., Harnack, L. J., Potter, J. D., Slager, S. L., Smyrk, T. C., Thibodeau, S. N., Cerhan, J. R., & Limburg, P. J. (2012). Cigarette smoking and colorectal cancer risk by KRAS mutation status among older women. Am J Gastroenterol, 107(5), 782-789.
PMID 22349355

2011

Chang, C. M., Wang, S. S., Dave, B. J., Jain, S., Vasef, M. A., Weisenburger, D. D., Cozen, W., Davis, S., Severson, R. K., Lynch, C. F., Rothman, N., Cerhan, J. R., Hartge, P., & Morton, L. M. (2011). Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study. Int J Cancer, 129(4), 938-947.
PMID 20949561

Chaturvedi, A. K., Engels, E. A., Pfeiffer, R. M., Hernandez, B. Y., Xiao, W., Kim, E., Jiang, B., Goodman, M. T., Sibug-Saber, M., Cozen, W., Liu, L., Lynch, C. F., Wentzensen, N., Jordan, R. C., Altekruse, S., Anderson, W. F., Rosenberg, P. S., & Gillison, M. L. (2011). Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol, 29(32), 4294-4301.

Gaudet, M. M., Press, M. F., Haile, R. W., Lynch, C. F., Glaser, S. L., Schildkraut, J., Gammon, M. D., Douglas Thompson, W., & Bernstein, J. L. (2011). Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger. Breast Cancer Res Treat, 130(2), 587-597.
PMID 21667121

Morton, L. M., Cerhan, J. R., Hartge, P., Vasef, M. A., Neppalli, V. T., Natkunam, Y., Dogan, A., Dave, B. J., Jain, S., Levy, R., Lossos, I. S., Cozen, W., Davis, S., Schenk, M. J., Maurer, M. J., Lynch, C. F., Rothman, N., Chatterjee, N., Yu, K., . . . Wang, S. S. (2011). Immunostaining to identify molecular subtypes of diffuse large B-cell lymphoma in a population-based epidemiologic study in the pre-rituximab era. Int J Mol Epidemiol Genet, 2(3), 245-252.
PMID 21915363

Razzak, A. A., Oxentenko, A. S., Vierkant, R. A., Tillmans, L. S., Wang, A. H., Weisenberger, D. J., Laird, P. W., Lynch, C. F., Anderson, K. E., French, A. J., Haile, R. W., Harnack, L. J., Slager, S. L., Smyrk, T. C., Thibodeau, S. N., Cerhan, J. R., & Limburg, P. J. (2011). Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women. Cancer Prev Res (Phila), 4(12), 2035-2043.
PMID 21900595

Sy, M. S., Altekruse, S. F., Li, C., Lynch, C. F., Goodman, M. T., Hernandez, B. Y., Zhou, L., Saber, M. S., Hewitt, S. M., & Xin, W. (2011). Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository. Cancer Biomark, 10(6), 251-258. PMID 22820080

2010

Chang, C. M., Schroeder, J. C., Huang, W. Y., Dunphy, C. H., Baric, R. S., Olshan, A. F., Dorsey, K. C., Dent, G. A., Cerhan, J. R., Lynch, C. F., Rothman, N., Cantor, K. P., & Blair, A. (2010). Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control study. Leuk Res, 34(2), 190-195.
PMID 19505720

Chang, C. M., Schroeder, J. C., Olshan, A. F., Dunphy, C. H., Huang, W. Y., Baric, R. S., Conway, K., Cerhan, J. R., Lynch, C. F., Rothman, N., Cantor, K. P., & Blair, A. (2010). A case-control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression. Cancer Causes Control, 21(7), 1147-1154. http://download.springer.com/static/pdf/544/art%253A10.1007%252Fs10552-010-9531-8.pdf?auth66=1419370017_839ae4016777026e683f0431d457f878&ext=.pdf

Limsui, D., Vierkant, R. A., Tillmans, L. S., Wang, A. H., Weisenberger, D. J., Laird, P. W., Lynch, C. F., Anderson, K. E., French, A. J., Haile, R. W., Harnack, L. J., Potter, J. D., Slager, S. L., Smyrk, T. C., Thibodeau, S. N., Cerhan, J. R., & Limburg, P. J. (2010). Cigarette smoking and colorectal cancer risk by molecularly defined subtypes. J Natl Cancer Inst, 102(14), 1012-1022.
PMID 20587792

Prior to 2010

Lal, G., Hashimi, S., Smith, B. J., Lynch, C. F., Zhang, L. R., Robinson, R. A., & Weigel, R. J. (2009). Extracellular Matrix 1 (ECM1) Expression Is a Novel Prognostic Marker for Poor Long-Term Survival in Breast Cancer: A Hospital-Based Cohort Study in Iowa. Annals of surgical oncology, 16(8), 2280-2287. https://doi.org/10.1245/s10434-009-0533-2

Takikita, M., Altekruse, S., Lynch, C. F., Goodman, M. T., Hernandez, B. Y., Green, M., Cozen, W., Cockburn, M., Saber, M. S., Topor, M., Zeruto, C., Abedi-Ardekani, B., Reichman, M. E., & Hewitt, S. M. (2009). Associations between Selected Biomarkers and Prognosis in a Population-Based Pancreatic Cancer Tissue Microarray. Cancer research, 69(7), 2950-2955. https://doi.org/10.1158/0008-5472.Can-08-3879

Worrillow, L. J., Smith, A. G., Scott, K., Andersson, M., Ashcroft, A. J., Dores, G. M., Glimelius, B., Holowaty, E., Jackson, G. H., Jones, G. L., Lynch, C. F., Morgan, G., Pukkala, E., Scott, D., Storm, H. H., Taylor, P. R., Vyberg, M., Willett, E., Travis, L. B., & Allan, J. M. (2008). Polymorphic MLH1 and risk of cancer after methylating chemotherapy for Hodgkin lymphoma. J Med Genet, 45(3), 142-146.
PMID 17959715

Bonner, M. R., Bennett, W. P., Xiong, W. Y., Lan, Q., Brownson, R. C., Harris, C. C., Field, R. W., Lubin, J. H., & Alavanja, M. C. R. (2006). Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women. International Journal of Cancer, 119(6), 1462-1467. https://doi.org/10.1002/ijc.22002

Thyagarajan, B., Anderson, K. E., Folsom, A. R., Jacobs, D. R., Lynch, C. F., Bargaje, A., Khaliq, W., & Gross, M. D. (2006). No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women’s Health Study. Cancer Detection and Prevention, 30(4), 313-321. https://doi.org/10.1016/j.cdp.2006.07.002

Goodman, M. T., Hernandez, B. Y., Hewitt, S., Lynch, C. F., Cote, T. R., Frierson, H. F., Jr., Moskaluk, C. A., Killeen, J. L., Cozen, W., Key, C. R., Clegg, L., Reichman, M., Hankey, B. F., & Edwards, B. (2005). Tissues from population-based cancer registries: a novel approach to increasing research potential. Hum Pathol, 36(7), 812-820.
PMID 16084952

Thyagarajan, B., Anderson, K. E., Kong, F., Selk, F. R., Lynch, C. F., & Gross, M. D. (2005). New approaches for genotyping paraffin wax embedded breast tissue from patients with cancer: the Iowa women’s health study. J Clin Pathol, 58(9), 955-961.
PMID 16126877

Field, R. W., Smith, B. J., Platz, C. E., Robinson, R. A., Neuberger, J. S., Brus, C. P., & Lynch, C. F. (2004). Lung cancer histologic type in the surveillance, epidemiology, and end results registry versus independent review.[see comment]. Journal of the National Cancer Institute, 96(14), 1105-1107. http://jnci.oxfordjournals.org/content/96/14/1105.full.pdf

Leonard, D. G., Travis, L. B., Addya, K., Dores, G. M., Holowaty, E. J., Bergfeldt, K., Malkin, D., Kohler, B. A., Lynch, C. F., Wiklund, T., Stovall, M., Hall, P., Pukkala, E., Slater, D. J., & Felix, C. A. (2002). p53 mutations in leukemia and myelodysplastic syndrome after ovarian cancer.[erratum appears in Clin Cancer Res. 2002 Aug;8(8):2752-3]. Clinical Cancer Research, 8(5), 973-985. http://clincancerres.aacrjournals.org/content/8/5/973.full.pdf

Schroeder, J. C., Olshan, A. F., Dent, R. B., Weinberg, C. R., Yount, B., Cerhan, J. R., Lynch, C. F., Schuman, L. M., Tolbert, P. E., Rothman, N., Cantor, K. P., & Blair, A. (2002). A case-control study of tobacco use and other non-occupational risk factors for t(14;18) subtypes of non-Hodgkin’s lymphoma (United States). Cancer Causes & Control, 13(2), 159-168.

Schroeder, J. C., Olshan, A. F., Baric, R., Dent, G. A., Weinberg, C. R., Yount, B., Cerhan, J. R., Lynch, C. F., Schuman, L. M., Tolbert, P. E., Rothman, N., Cantor, K. P., & Blair, A. (2001). Agricultural risk factors for t(14;18) subtypes of non-Hodgkin’s lymphoma. Epidemiology, 12(6), 701-709.
PMID 11679800

Behrens, C., Travis, L. B., Wistuba, II, Davis, S., Maitra, A., Clarke, E. A., Lynch, C. F., Glimelius, B., Wiklund, T., Tarone, R., & Gazdar, A. F. (2000). Molecular changes in second primary lung and breast cancers after therapy for Hodgkin’s disease. Cancer Epidemiol Biomarkers Prev, 9(10), 1027-1035.
PMID 11045784

Lynch, C. F., Kutza, J. A., Kelley, S. L., & Platz, C. E. (1999). Procurement of population-based cancer tissue in Iowa. Mod Pathol, 12(4), 422-426.
PMID 10229508

Khan, M. A., Travis, L. B., Lynch, C. F., Soini, Y., Hruszkewycz, A. M., Delgado, R. M., Holowaty, E. J., van Leeuwen, F. E., Glimelius, B., Stovall, M., Boice, J. D., Jr., Tarone, R. E., & Bennett, W. P. (1998). p53 mutations in cyclophosphamide-associated bladder cancer. Cancer Epidemiol Biomarkers Prev, 7(5), 397-403.
PMID 9610789

Platz, C. E., Cohen, M. B., Jones, M. P., Olson, D. B., & Lynch, C. F. (1996). Is microstaging of early invasive cancer of the urinary bladder possible or useful? Modern Pathology, 9(11), 1035-1039.

 

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